422 21st Street

Rare and storied mixed-use opportunity situated on a highly visible 6,270-square-foot corner lot in the heart of Five Points. The property features a historic five-bedroom residence and a separate office building, totaling approximately 6,565 square feet of improvements on a single parcel. Ideally positioned just steps from Benedict Fountain Park, the RTD 27th & Welton Light Rail Station, neighborhood coffee shops and restaurants, and only minutes from Downtown Denver and Uptown, the property offers an exceptional blend of urban convenience, historic character, and neighborhood connectivity. The property includes an approximately 2,565-square-foot historic residence with five bedrooms and two bathrooms, currently operating as a successful Airbnb and providing immediate income or the opportunity for owner occupancy. Tucked behind the residence is a rare, private rear patio, offering an inviting outdoor retreat ideal for entertaining, relaxing, or complementing a live/work lifestyle—an uncommon amenity for a property so close to downtown. Complementing the residence is a separate office duplex totaling approximately 4,000 square feet, comprised of two approximately 2,000-square-foot office suites, one of which is currently leased on a month-to-month basis, providing immediate cash flow while preserving flexibility for future occupancy, repositioning, or redevelopment. Located within the Clements Historic District, this unique property offers exceptional visibility, walkability, and access to some of Denver’s most desirable dining, entertainment, cultural, and transit amenities. Whether envisioned as an investment, corporate headquarters with supplemental income, creative office campus, live/work environment, boutique hospitality concept, or long-term repositioning opportunity, this one-of-a-kind asset presents remarkable versatility in one of Denver’s most vibrant and historically significant neighborhoods.

Property Details

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Based on information submitted to the MLS GRID as of 2026-09-10 03:22:38 UTC. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

Last Updated: Sep 10, 2026 3:22 AM. Source: RECOLORADO

Provided By
Listed by Karen Zeile (#46f41880c3c270456b6d93c35982573d), karen@kentwoodcommercial.com,303-947-3665
Listing Office: Kentwood Commercial, Llc

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